Sodium Channels as Targets for Volatile Anesthetics
نویسندگان
چکیده
منابع مشابه
Sodium Channels as Targets for Volatile Anesthetics
The molecular mechanisms of modern inhaled anesthetics are still poorly understood although they are widely used in clinical settings. Considerable evidence supports effects on membrane proteins including ligand- and voltage-gated ion channels of excitable cells. Na(+) channels are crucial to action potential initiation and propagation, and represent potential targets for volatile anesthetic ef...
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G protein-gated inwardly rectifying potassium channels (GIRKs) are a family of homo- and hetero-oligomeric K(+) channels composed of different subunits (GIRK1 to 4 in mammals). GIRK4 and GIRK1 are found mainly in the atrium, whereas neuronal cells predominantly express the GIRK1, GIRK2, and GIRK3 isoforms. When activated, GIRK channels slow the firing rate of atrial myocytes and neuronal cells....
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Corresponding author: Sungsik Park, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Samduk-2 ga, Joong-gu, Daegu 700-721, Korea. Tel: 82-53-420-5863, Fax: 82-53-426-2760, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativeco...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2012
ISSN: 1663-9812
DOI: 10.3389/fphar.2012.00050